Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway
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چکیده
منابع مشابه
Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats
Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory. BDNF exerts its functions via tropomyosin receptor kinase B (TrkB). BDNF transcription is regulated by stimulating CREB phosphorylation. The CREB-TrkB-BDNF pathway is rep...
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BACKGROUND The immature brain is more susceptible to seizures than mature brains but less vulnerable to seizure-induced neuronal loss. We studied age-related susceptibility and vulnerability to kainic acid-induced status epilepticus (KASE) in rats in terms of hippocampal expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B receptor (TrkB). METHODS Immunohistochemical a...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2020
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2020.110353